Associations of vascular risk factors and APOE genotype with perivascular spaces among community‐dwelling older adults
Journal of the American Heart Association Aug 21, 2020
Laveskog A, Wang R, Vetrano DL, et al. - Researchers undertook this population‐based study to examine if there exists a correlation of vascular risk factors with visible perivascular space (PVS) in older adults. Participants were selected from the Swedish National study on Aging and Care in Kungsholmen (2001–2003), and included 530 individuals (age ≥ 60 years) who were free from dementia and functional dependence. Via this work, experts gained limited evidence in support of a correlation of magnetic resonance imaging–visible PVS with traditional vascular risk factors among older adults. Among APOE ε4 carriers, a link of orthostatic hypotension with lobar PVS was identified, which is indicative of a likely role of lobar PVS as a marker for amyloid‐associated small‐vessel disease.
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