Looman KIM, van Meel ER, Grosserichter-Wagener C, et al. - Given novel insights into immune cells could add to treatment and monitoring of atopic disease, and since nongenetic factors shape the human immune system, therefore, researchers used a large cohort of atopic children in order to analyze these immune cells, with adjustment for prenatal and postnatal confounders. From children (n = 855, 10-year-old) within the Generation R cohort, data regarding atopic dermatitis, inhalant- and food-allergic sensitization, asthma lung function scores were collected. They utilized 11-color flow cytometry to ascertain CD27⁺ and CD27⁻IgG⁺, IgE⁺ and IgA⁺ memory B cells, Th1, Th2, Th17, and Treg-memory cells from venous blood. Findings revealed higher circulating memory Treg cells, but not higher IgE⁺B-cell numbers, in children having any atopic disease and children having inhalant- and food-allergic sensitization or atopic dermatitis. TGF-β-mediated compensation for chronic inflammation was suggested by the observed links of higher Treg and CD27⁺IgA⁺ B-cell numbers in children having food-allergic sensitization.