Michel C, Schmidt SJ, Schnyder N, et al. - Researchers sought to provide insight into factors related to poor quality of life (QoL) and self-rated health (SRH) in clinical high-risk (CHR) for psychosis. Telephone interviews of 2,683 (baseline) and 829 (3-year follow-up) individuals of the Swiss Canton of Bern (age-at-baseline: 16–40 years) were undertaken to query CHR symptoms. They used the Schizophrenia Proneness Instrument for basic symptoms, the Structured Interview for Psychosis-Risk Syndromes for ultra-high risk (UHR) symptoms, the Mini-International Neuropsychiatric Interview for current axis-I disorders, the Brief Multidimensional Life Satisfaction Scale for QoL, and the 3-level EQ-5D for SRH. In cross-sectional structural equation modeling, higher age, male gender, lower education, and somatoform disorders exhibited an exclusively significant association with lower SRH. An exclusive association of only eating disorders with poor QoL was observed. Furthermore, there was an independent association of both strongly interrelated constructs with affective, and anxiety disorders, UHR and, more strongly, with basic symptoms. Prospectively, lower education and anxiety disorders at baseline predicted lower SRH, while affective disorders at baseline predict poorer QoL.