Rifas-Shiman SL, et al. - In the present study, the researchers used linear regression models adjusted for potential confounders to examine correlations of acetaminophen and ibuprofen use during pregnancy and infancy with children's executive function and behaviour problems as reported by parents and classroom teachers in the pre-birth cohort study Project Viva. They involved 1,225 mother-child pairs from Project Viva, a pre-birth cohort study. Data reported that 46.1% of mothers used acetaminophen ≥ 10 times and 18.4% used any ibuprofen during pregnancy. It was noted that 65.3% and 39.6% of infants received acetaminophen and ibuprofen ≥ 6 times, respectively, in the first year. Findings suggested an association of prenatal and early-life exposure to acetaminophen and ibuprofen with poorer executive function and behaviour in childhood. Such results emphasize the need for further research on the mechanisms through which analgesics can act on fetal and child brain development.