Novick TK, Surapaneni A, Shin JI, et al. - Researchers performed this study on adult primary care patients in Geisinger Health (Danville, PA) between 2008 and 2017, to assess opioid-related risks of mortality and hospitalization across the range of eGFR. They propensity matched the individuals taking their first opioid prescription to those taking NSAIDS (and, in sensitivity analysis, gabapentinoids). Comparisons were performed for the risk of death and hospitalization, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents across time-varying eGFR. In this study, a higher risk of death and hospitalization was observed in relation to the receipt of prescription opioids vs other pain medications, especially with higher doses and at lower eGFR.