Associations of maternal early-pregnancy glucose concentrations with placental hemodynamics, blood pressure and gestational hypertensive disorders
American Journal of Hypertension Apr 28, 2020
Erkamp JS, Geurtsen ML, Duijts L, et al. - In view of association between gestational diabetes mellitus with increased risks of gestational hypertension and preeclampsia, researchers investigated if high maternal glucose concentrations in early pregnancy are correlated with adverse placental adaptations and subsequently altered utero-placental hemodynamics during pregnancy, predisposing to an elevated risk of gestational hypertensive disorders. They conducted a population-based prospective cohort study among 6,078 pregnant women from early pregnancy onwards. These women were assessed for early-pregnancy non-fasting glucose concentrations and mid and late pregnancy uterine and umbilical artery resistance indices. Measurement of maternal blood pressure was performed in early, mid and late pregnancy and assessment of the occurrence of gestational hypertensive disorders was done using hospital registries. Outcomes revealed correlation of maternal early-pregnancy non-fasting glucose concentrations within the normal range with blood pressure in early pregnancy, but these seemed not affecting placental hemodynamics and the risks of gestational hypertensive disorders.
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