Quesada O, Claggett B, Rodriguez F, et al. - A positive correlation of insulin resistance with both systolic blood pressure (SBP) and diastolic BP was identified in a large community-based sample of Hispanic/Latino adults of diverse national backgrounds not taking antihypertensive medications and free from diabetes. Findings suggest that insulin resistance may adversely affect the vasculature before the development of dysglycemia, and this correlation appeared stronger in women than in men.

• This cross-sectional analysis included 10,810 HCHS/SOL (Hispanic Community Health Study/Study of Latinos) participants; their mean (SD) age was 37.2 (13.4) years.

• Among these participants, 52% were women, 39% had prediabetes and 26% had stage 1 or 2 hypertension.

• Insulin resistance was quantified by homeostasis model assessment of insulin resistance (HOMA-IR).

• HOMA-IR showed a significant linear correlation with both SBP and diastolic BP.

• There was a significant interaction with gender and the correlation between HOMA-IR and SBP; the correlation was linear in men and nonlinear in women.