Associations of growth and body composition with brain size in preterm infants
The Journal of Pediatrics Aug 03, 2019
Bell KA, Matthews LG, Cherkerzian S, et al. - Using generalized estimating equations, researchers evaluated the connection of very preterm infants' brain size (bifrontal diameter, biparietal diameter, transverse cerebellar distance) at term-equivalent age with physical growth (Z-score change from birth to term) from birth to term and body composition (fat and fat-free mass) at term. Sixty-two infants born at < 33 weeks of gestation were studied. Data reported that the median gestational age was 29 weeks (range, 24.0-32.9 weeks). Findings suggested an association of positive gains in weight and body mass index Z-score with increased brain size. Investigators found that weight and body mass index gain from birth to term, and ultimately lean mass—but not fat—at term, were correlated with larger brain size. Factors promoting lean mass accrual among preterm infants may also encourage brain growth.
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