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Associations of fat mass and fat-free mass accretion in infancy with body composition and cardiometabolic risk markers at 5 years: The Ethiopian iABC birth cohort study

PLoS Medicine Sep 08, 2019

Wibaek R, Vistisen D, Girma T, et al. - Researchers examined the influence of fat mass (FM) and fat-free mass (FFM) at birth and their accretion during infancy on body composition and cardiometabolic risk markers at 5 years. In the Infant Anthropometry and Body Composition (iABC) birth cohort between December 2008 and October 2012, they enrolled healthy children born at term at Jimma University Specialized Hospital in the city of Jimma, Ethiopia. They used air displacement plethysmography a median of 6 times between birth and 6 months of age to assess FM and FFM. Individual FM and FFM at birth and their accretion over 0–3 and 3–6 months of age were estimated in 507 children using linear-spline mixed-effects modeling. They studied a total of 340 children at the 5-year follow-up (mean age: 60.0 months; girls: 50.3%; mean wealth index: 45.5 out of 100; breastfeeding status at 4.5 to 6 months postpartum: 12.5% exclusive, 21.4% almost exclusive, 60.6% predominant, 5.5% partial/none). Findings suggest a positive association of FM accretion in early life with markers of adiposity and lipid metabolism, however, it was not associated with blood pressure and cardiometabolic markers related to glucose homeostasis. They observed a prime relation of FFM accretion with linear growth and FFM at 5 years.
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