Wang F, et al. - Through a study that involved 1,621 community-dwelling Chinese participants who were aged 50-70 years without hyperuricemia at baseline, with a mean duration of follow-up 6 years, the researchers intended to analyze metabolomics profiles in relation to uric acid change and incident hyperuricemia. Nine risk metabolites (cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines C14:1OH, C18, C18:2, C20, and C20:4) were recognized as markedly related to uric acid change and incident hyperuricemia, post-adjustment for standard risk factors. A significant correlation was portrayed by the network analysis between the module comprising of long-chain acylcarnitines and incident hyperuricemia. Moreover, the consumption of foods like red and processed meat or soy products were related to levels of 9 metabolites that were determined. Therefore, a positive association of plasma cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines with incident hyperuricemia was ascertained. Furthermore, the levels of these metabolites could be partially induced by the consumption of meat and soy products that are correlated with hyperuricemia.