Houtepen LC, et al. - A prospective cohort study was conducted to explore relationships of adverse childhood experiences (ACEs) with educational attainment and adolescent health and the role of family and socioeconomic factors in these associations. Researchers tried to find out the relationships of ACEs between birth and 16 years (sexual, physical, or emotional abuse; emotional neglect; parental substance abuse; parental mental illness or suicide attempt; violence between parents; parental separation; bullying; and parental criminal conviction, with data collected on multiple occasions between birth and age 16) with educational attainment at 16 years (n = 9,959) and health at age 17 years (depression, obesity, harmful alcohol use, smoking, and illicit drug use; n = 4,917) utilizing data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective cohort of children born in southwest England in 1991–1992. This research indicates correlations between ACEs and lower educational attainment and higher risks of depression, drug use, and smoking that remain after adjustment for family and socioeconomic factors. The low PAFs for both ACEs and socioeconomic factors suggest that interventions that concentrate solely on ACEs or solely on socioeconomic deprivation, whilst useful, would miss most cases of adverse educational and health results. It was reported that the interpretation implies that intervention strategies should target a wide range of relevant factors, involving ACEs, socioeconomic deprivation, parental substance use, and mental health.