Lane CA, Barnes J, Nicholas JM, et al. - In a propective cohort of 463 candidates free of dementia from the population-based Insight 46 study, researchers explored the links between vascular risk in early adulthood, midlife, and late life with late-life brain structure and pathology utilizing measures of white matter–hyperintensity volume, β-amyloid load, and whole-brain and hippocampal volumes. Candidates with at least 1 available imaging measure, vascular risk measurements at 1 or more points, and no dementia were involved. Findings suggested an association of higher vascular risk with smaller whole-brain volume and greater white matter–hyperintensity volume at age 69 to 71 years, with the strongest relationship observed with early adulthood vascular risk. There was no proof that higher vascular risk affects amyloid deposition, at least up to 71 years of age. To maximize late-life brain health, reducing vascular risk with appropriate interventions should be considered from early adulthood.