Groenewald CB, et al. - Among adolescents who were previously opioid naive, researchers sought to evaluate connections between the type of opioid, quantity dispensed, daily dose, and overdose risk. The sample consisted of 1,146,412 privately insured adolescents ages 11 to 17 years in the United States captured in the Truven MarketScan commercial claims data set from January 2007 to September 2015. Seven hundred twenty-five candidates experienced an opioid overdose among the cohort, and the overall rate of overdose events was 28 events per 100,000 observed patient-years. According to this retrospective analysis, one of 1,600 previously opioid-naive adolescents receiving an opioid prescription experienced an opioid overdose a median of 1.75 years later leading to medical care. Preexisting mental health conditions, use of tramadol, and a higher number of dispensed tablets (>30 vs <18) have been linked to an increased risk of an overdose of opioids.