Qeadan F, et al. - Researchers conducted a retrospective cohort study using data from the Health Facts Database with the aim to determine if in clinical contexts, naloxone prescribing targeted pain patients most at risk for opioid overdose. They followed up three patient groups for 2 years: individuals with shoulder or long bone fractures (n = 252,424), chronic pain syndrome (CPS) (n = 76,141), or non-traumatic low back pain (n = 792,956) who received an opioid prescription. Among these patients, 0.16% [average follow-up time to overdose (AFU)= 240 days], 1.28% (AFU= 244 days), and 0.30% (AFU= 264 days) had an occurrence of opioid overdoses, respectively. Findings suggest association of receiving a naloxone prescription with raised risk of subsequent opioid overdose among patients with acute and chronic pain, indicating prescribers often recognize patients most in need of naloxone.