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Associations between maternal serum HDL-c concentrations during pregnancy and neonatal birth weight: A population-based cohort study

Lipids in Health and Disease May 20, 2020

Wang H, Dang Q, Zhu H, et al. - In this population-based cohort study, researchers intended to determine if there is a connections between maternal serum concentrations of high-density lipoprotein cholesterol (HDL-c) throughout pregnancy and neonatal birth weight (BW) and small for gestational age (SGA) births. Between January 2014 and December 2017, 2,241 pregnant women was followed from recruitment to delivery in three hospitals in Beijing, China. Linear regression and linear mixed-effects models estimated the links between maternal HDL-c and BW. Findings suggested an inverse association of maternal serum HDL-c concentrations with BW at 24th and 36th gestational weeks. At the 36th gestational week, the high concentrations of HDL-c increased the risk of SGA. The maternal HDL-c trend of change across pregnancy has been correlated with smaller neonatal size.

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