Stevens WW, Peters AT, Tan BK, et al. - Researchers investigated links between inflammatory endotypes and clinical presentations in chronic rhinosinusitis (CRS). Patients with nonpolypoid CRS (CRSsNP) (n = 121) were compared with patients with polypoid CRS (CRSwNP) (n = 134) and markers including IFN-γ [T1 (type 1)], eosinophil cationic protein [T2 (type 2)], Charcot-Leyden crystal galectin (T2), and IL-17A [T3 (type 3)] were used to determine inflammatory endotypes. A significant association of the presence of nasal polyps, asthma comorbidity, smell loss, and allergic mucin, with the presence of T2 endotype, was observed in all patients with CRS. A significant link of the presence of pus with T3 endotype was noted in all patients with CRS. In both CRSsNP and CRSwNP, the link of smell loss with T2 endotype and of pus with the T3 endotype was observed on further evaluating these links in CRSsNP and CRSwNP separately. A tendency to have clinical presentations shared by both T2 and T3 endotypes was observed in patients with CRS with T2 and T3 mixed endotype. In CRS, a direct link of clinical presentations with inflammatory endotypes was shown. More accurate and personalized medical treatments in CRS may be provided by the detection of inflammatory endotypes.