Vancampfort D, et al. - Researchers investigated the association between muscular strength (measured by maximal handgrip) and mild cognitive impairment (MCI) in six low- and middle-income countries (LMICs; China, Ghana, India, Mexico, Russia, South Africa) via analyzing cross-sectional, community-based data on individuals aged ≥50 years from the World Health Organization's Study on Global Ageing and Adult Health. Including 32,715 participants (mean age 62.± SD 15.6 years and 51.7% female), they identified the prevalence of MCI and weak handgrip strength of 15.3% and 46.5%, respectively. Weak handgrip strength was noted to be correlated with 1.41 times higher odds for MCI after adjustment for potential confounders, indicating the clinical utility of muscular weakness as an indicator of MCI risk. Findings may assist in the development and broader implementation of resistance-training interventions targeting both physical and cognitive health.