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Associations between epicardial adipose tissue, subclinical atherosclerosis and high-density lipoprotein composition in type 1 diabetes

Cardiovascular Diabetology Dec 12, 2018

Colom C, et al. - Researchers examined 72 long-term patients with type 1 diabetes (T1DM) without clinical atherosclerosis, to study the link between epicardial adipose tissue (EAT) volume, subclinical atherosclerosis, and high-density lipoprotein (HDL) composition in T1DM. They used cardiac computed tomography angiography to determine EAT volume and subclinical atherosclerosis. An EAT index (iEAT) was obtained by adjusting EAT according to body surface. They also examined HDL composition. The subjects with the presence of clinical coronary heart disease were not included in this study. Findings revealed association between alterations in the composition of HDL in TIDM and increased iEAT and the presence of subclinical atherosclerosis. These abnormalities of HDL composition could be useful to identify T1DM patients at highest cardiovascular risk.
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