Masuda T, et al. - In this systematic review and meta-analysis of 63 cohort studies involving 109,341 individuals, researchers contrasted several outcomes of clozapine vs oral nonclozapine second-generation antipsychotics (NC-SGAs) in cohort studies. In comparison with NC-SGAs, clozapine was significantly related to lower hospitalization risk and all-cause discontinuation regardless of greater illness severity. Relationships were statistically important for comparisons with quetiapine fumarate and aripiprazole concerning hospitalization and all NC-SGAs, for all-cause discontinuation, except aripiprazole. Clozapine was also significantly correlated with superior outcomes relative to overall symptoms and Clinical Global Impressions scale severity. Clozapine was significantly related to progress in body weight, BMI, and T2DM. Thus, in cohort studies, the use of clozapine was related to superior chief efficiency outcomes and greater cardiometabolic-related risk outcomes vs NC-SGAs irrespective of more critically ill individuals being treated with clozapine.