Alosco ML, Stein TD, Tripodis Y, et al. - In 180 deceased men older than 40 years who played football and had chronic traumatic encephalopathy (CTE), researchers examined the connection of white matter rarefaction and cerebrovascular disease with dementia. According to findings, more years of football play were linked to more severe white matter rarefaction and greater dorsolateral frontal cortex (DLFC) neurofibrillary tangle (NFT) burden among older men who had played football and had CTE. Dementia was independently correlated with white matter rarefaction, arteriolosclerosis, and DLFC NFTs. Changes in neuropathology, including white matter rarefaction and phosphorylated tau, related with repetitive head effect as well as pathological modifications not connected with head trauma, such as arteriolosclerosis, are what most likely causes dementia in CTE.