Alosco ML, Stein TD, Tripodis Y, et al. - In this cross-sectional study of 180 deceased people older than 40 years who had played football and had chronic traumatic encephalopathy (CTE), experts examined the relationship of white matter rarefaction and cerebrovascular disease with dementia in deceased men older than 40 years who played football and had CTE. Among elderly men who had played football and had CTE, more years of football play were related to more serious white matter rarefaction and greater dorsolateral frontal cortex (DLFC) neurofibrillary tangles (NFTs) burden. White matter rarefaction, arteriolosclerosis, and DLFC NFTs were irrespectively correlated with dementia. Dementia in CTE is possibly a result of neuropathologic variations, including white matter rarefaction and phosphorylated tau, related to repetitive head impression and pathologic alterations not correlated to head trauma, like arteriolosclerosis.