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Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: A multinational study

Rheumatology Feb 05, 2021

Moiseev S, Kronbichler A, Makarov E, et al. - In this study, the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK, and North America was evaluated. Researchers included patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation. They retrospectively obtained data on VTE, including either deep vein thrombosis or pulmonary embolism from tertiary vasculitis centers. The odds ratios (ORs) and 95% confidence intervals were calculated by using univariate and multivariate regression models. A total of 2869 AAV patients were included in the study. It has been reported that two-thirds of VTE occurred during the initial phase of active disease. They verified previous findings from smaller studies that a decrease in kidney function, skin involvement, and pulmonary disease are independently correlated with VTE.

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