Brander G, et al. - In this longitudinal population-based cohort study of 14,045,026 individuals living in Sweden between January 1, 1973 and December 31, 2013, researchers examined the risk of metabolic and cardiovascular disorders among people with Tourette syndrome (TS) or chronic tic disorder (CTD) over a period of 40 years. In particular, people with TS or CTD were at higher risk of obesity, type 2 diabetes and circulatory system diseases. The risk of any cardiometabolic disorder in males was significantly higher than in females, as was the risk of obesity. Patients with a longer duration of antipsychotic treatment (>1 year) had significantly lower risks of metabolic and cardiovascular disorders vs patients with TS or CTD who were not taking antipsychotics. Outcomes suggested that patients with TS and CTD have a significant risk of metabolic and cardiovascular disorders. The results emphasize the importance of carefully monitoring cardiometabolic health in patients with TS or CTD over a lifetime, especially in patients with comorbid attention-deficit/hyperactivity disorder.