de Luis DA, et al. – This study entailed the determination of the impact of rs10830963 MTNR1B variant in association with body weight loss, insulin resistance and adipokine levels in response to a hypocaloric diet with Mediterranean pattern. In obese subjects, a link was apparent, between rs10830963 MTNR1B single nucleotide polymorphism and body weight loss and changes in fasting insulin levels and HOMA–insulin resistance (IR), respectively.

Methods

• Researchers studied a Caucasian population of 80 obese patients, before and after 12 weeks on a hypocaloric diet.
• They measured body weight, fat mass, waist circumference, blood pressure, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), lipoprotein levels and adipocytokines levels (leptin, adiponectin and resistin).
• They also assessed genotype of MTNR1B gene single nucleotide polymorphism (rs10830963).

Results

• Findings demonstrated that overall, 44 patients (55%) had the genotype CC, 27 patients CG (33.8%) and 9 patients GG (11.2%).
• Data revealed that, with the dietary intervention body mass index, weight, fat mass, systolic blood pressure, leptin levels and waist circumference decreased in both groups.
• Researchers observed that there were no significant differences between gender groups on the reported effects in each genotype group.
• However, they noted that the improvement of anthropometric parameters was higher in subjects with CC genotype than (GC+GG) genotype.
• Data revealed that after dietary intervention and in males with CC genotype, insulin levels (-5.3+4.8 UI/L vs 1.2+4.1 UI/L;p<0.05) and HOMA-IR (-1.4+2.1 units vs 0.4+2.0 units;p<0.05) decreased.
• In addition, it was shown that in the group of females with CC genotype, insulin levels (-3.5+2.1 UI/L vs. -1.4+2.2 UI/L: p<0.05) and HOMA-IR (-1.4+1.2 units vs. -0.1+1.3 units: p<0.05) decreased, too.
• However, data highlighted that these parameters remained unchanged in (GC+GG) group.
• It was also shown that fasting glucose levels were higher in patients in (GC+GG).