Ebrazeh M, Ezzatifar F, Torkamandi S, et al. - In this study, the relationship of ERAP2 gene single nucleotide polymorphisms (SNPs) with ankylosing spondylitis (AS) predisposition was explored in Iranian patients and determined their effect on the inflammatory state of the patients. DNA was extracted from the whole blood of 250 AS patients and 250 healthy individuals for genotyping of rs2548538, rs2287988, and rs17408150 SNPs using a real‐time allelic discrimination approach. Researchers applied an enzyme‐linked immunosorbent assay to assess the serum concentration on the cytokines. This study’s findings demonstrated that ERAP2 gene rs2287988 and rs17408150 SNPs are correlated with susceptibility to AS, but they are probably not ascertaining the levels of IL‐17A, IL‐23, and IL‐10 in this disease.