Vorobeľová L, Danková Z, Candráková-Čerňanová V, et al. - Associations of the ESR1 (XbaI, PvuII) and the MLXIPL (rs3812316) gene polymorphisms with uric acid (UA) levels in Slovak midlife women, subdivided according to their menopause status, were investigated. Researchers investigated a total of 362 women (from 38 to 65 years of age) during their medical examination at local health centers with respect to a variety of aspects such as medical, anthropometrical, and lifestyle. A blood sample was obtained from participants for biochemical analyses and DNA genotyping. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), they detected the MLXIPL gene (rs3812316 SNP variant) and ESR1 gene (PvuII and XbaI) genotypes. Analysis of data was performed using general linear models and multiple linear regression analyses to adjust for risk factors elevating the UA level such as fat mass, triglycerides and creatinine. As per outcomes, they suggest a correlation between MLXIPL (rs3812316) polymorphism and higher serum UA levels. Higher UA levels were observed in women with the CC genotype than the G-allele carriers. In the postmenopausal cohort, there was a correlation between the ESR1 (XbaI) polymorphism and UA levels only. As per the Bonferroni pairwise comparison, in the postmenopausal period, the G-allele carriers had higher estimated UA marginal mean (269.7 μmol/L) than the AA-allele postmenopausal women.