Argalious MY, Steib J, Daskalakis N, et al. - Via including data from male American Society of Anesthesiologists III/IV patients ≥ 40 years of age who had cardiac surgery between May 2005 and March 2017 at the Cleveland Clinic (Cleveland, OH) main campus after institutional review board approval, researchers analyzed the effect of testosterone replacement on the incidence of a composite of postoperative in-hospital mortality and cardiovascular events. Of the 20,604 patients who met inclusion and exclusion requirements, 301 patients who regularly used testosterone within 1 month prior to the surgery were matched to 1505 patients out of 20,303 who did not use testosterone. Following cardiac surgery, preoperative testosterone is not linked to a statistically significant increased incidence of a composite of postoperative in-hospital mortality and cardiovascular events.