Ascher SB, et al. - Because HIV-infected individuals commonly develop chronic kidney disease (CKD), researchers examined if CKD onset and progression could be delayed using statins, which have cholesterol-lowering and pleiotropic effects. From the Multicenter AIDS Cohort Study, 850 HIV-infected men with stored urine samples (2009–2011) were assessed for cross-sectional correlations of statin use with urine biomarkers of kidney damage using multivariable linear regression. Among participants, 30% reported statin use. The analysis revealed an association of statin use with higher baseline ACR, but not with biomarkers of tubulointerstitial injury. Only participants with baseline proteinuria had modestly slower estimated glomerular filtration rate by creatinine decline in correlation with statin use. Despite susceptibility of the findings to confounding by indication, these results suggest a limited impact of statins on CKD risk among HIV-infected men.