Wang CY, et al. - Researchers conducted a case-control study of 1,008 patients who were undergoing Mohs reconstruction repaired by flap or graft, in order to assess the effect of smoking on postoperative outcomes in these patients. Among the 1,008 patients [396 women and 612 men; the median age: 70 (12) years (range, 21-90 years)], 128 patients (12.7%) were current smokers, 385 (38.2%) were former smokers, and 495 (49.1%) were never smokers. Multivariate logistic regression revealed increased risks of acute complications in correlation with current smoking, former smoking, larger defect size, and the use of free cartilage graft. For long-term complications, an increased risk was evident in correlation with central face location, use of interpolation flap or flap-graft combination, larger flap size, and basal cell carcinomas or other basaloid tumors, whereas a decreased risk was observed in correlation with increased age. These findings emphasize the significance of smoking as an important lifestyle factor that should be considered for preoperative planning and help to better quantify the magnitude of risk.