Winer JR, Deters KD, Kennedy G, et al. - Older adults (aged 65 to 85 years) experienced worse outcomes, including greater amyloid β (Aβ) burden, greater depressive symptoms, higher body mass index, and cognitive decline, in relation to both short (≤6 hours) and long (≥9 hours) sleep durations. This highlights that maintaining adequate sleep is important.

• This is a cross-sectional analysis of 4,417 older adults with normal cognition to examine the links between self-reported sleep duration and brain Aβ burden as well as the demographic, cognitive, and lifestyle variables.

• Short sleep duration was associated with a higher amyloid-β burden.

• Distinct deficits in cognitive performance as well as greater depressive symptoms, body mass index, and daytime napping were evident in relation to sleeping duration of 6 hours or less or 9 hours or more.