Aggarwal P, Hutcheson KA, Garden AS, et al. - Researchers conducted the study for identifying the risk factors of voice and speech symptoms among long-term survivors of oropharyngeal cancer (OPC). This retrospective cohort study with cross-sectional survivorship survey administration involves cancer-free survivors of OPC who were treated curatively at MD Anderson Cancer Center (Houston, Texas) between January 2000 and December 2013 and took part in a survey from September 2015 to July 2016. In total, 881 survivors of OPC were included in this investigation. Many treatment-related factors, including increasing total radiotherapy dose, multimodality induction and concurrent chemotherapy regimens, and continued smoking, as well as clinical and demographic factors, were identified as risk factors for moderate to severe voice and speech symptoms in this large OPC survivorship cohort study. The key findings of this study were the protective effects of split-field radiation, as well as the fact that longer-term survivors and those who continued to smoke had worse voice and speech symptoms. Such findings may help to guide future research and effective targeted clinical voice and speech preservation interventions, as well as smoking cessation interventions, in order to improve voice and speech function and quality of life in patients with OPC.