Hasegawa K, et al. - In this multicenter prospective cohort study involving 716 infants (median age was 2.9 months) who were hospitalized for bronchiolitis, researchers investigated the association of different viruses (respiratory syncytial virus [RSV], rhinovirus species) in bronchiolitis with risks of developing recurrent wheeze. According to results, rhinovirus C infection was linked to a higher risk of developing recurrent wheeze at the age of 3 years compared to RSV infection. In addition, infants with rhinovirus C infection and IgE sensitization (to food or aeroallergen) in infancy had 3-fold higher recurrent wheeze risks, whereas those without sensitization did not have significant differences. The study identifies infants at higher risk for recurrent wheeze development and informs strategies for developing targeted preventive therapies.