Chen P, et al. - In this cohort study of 18,185 people (9,233 females and 8,952 males), researchers investigated whether positive adolescent family relationships were related to decreased depressive symptoms among women and men as they begin midlife. Significantly lower levels of depressive symptoms from early adolescence to midlife were noted in women and men who encountered positive adolescent family relationships than those who encountered less positive adolescent family relationships. During the adolescent and early adulthood years, the decrease in depressive symptoms related to positive adolescent family relationships was greater for females vs males, following which females and males profited proportionately from positive adolescent relationships during young adulthood to midlife. In conclusion, the findings imply that among females and males from early adolescence to midlife, positive adolescent family relationships are related to superior mental health. Moreover, to promote healthy mental development during the life course, interventions in early family life seem to be significant.