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Association of polycystic ovary syndrome or anovulatory infertility with offspring psychiatric and mild neurodevelopmental disorders: A Finnish population-based cohort study

Human Reproduction Sep 04, 2020

Chen X, Kong L, Piltonen TT, et al. - Via a population-based cohort study in Finland, researchers assessed if and how maternal polycystic ovary syndrome (PCOS) is linked with risks for a wide variety of psychiatric and mild neurodevelopmental disorders in offspring. They assessed a total of 1,097,753 live births by 590,939 mothers between 1996 and 2014 and followed up with children until December 31, 2018 (up to the age of 22 years). Using national registries they compared data from 24,682 (2.2%) children born to mothers with PCOS vs 1,073,071 (97.8%) children born to mothers without PCOS. A neurodevelopmental or psychiatric disorder was diagnosed in a total of 105,409 (9.8%) children. Observations suggest that offsprings are at raised risks for almost all groups of psychiatric and mild neurodevelopmental disorders in correlation with maternal PCOS and/or anovulatory infertility independently or jointly with maternal obesity, perinatal problems, cesarean delivery and gestational diabetes. The offspring may see signs of the disorder in childhood or adolescence.

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