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Association of plasma lipoprotein(a) with long-term adverse events in patients with chronic kidney disease who underwent percutaneous coronary intervention

The American Journal of Cardiology May 18, 2018

Xu N, et al. - In an observational cohort study in patients with chronic kidney disease (CKD) who underwent percutaneous coronary intervention (PCI), researchers examined the link between plasma lipoprotein(a) [Lp(a)] and long-term clinical outcomes including 2-year risk of major adverse cardiovascular and cerebrovascular events (MACCE) and bleeding according to Bleeding Academic Research Consortium (BARC) definitions. Higher incidence of bleeding as well as higher risk of MACCE was reported in high Lp(a) vs low Lp(a) group, as revealed by Kaplan-Meier curves. In multivariable Cox regression analysis, high Lp(a) vs low Lp(a) was identified as an independent predictor of BARC bleeding. Overall, findings suggested a possible association of high Lp(a) value with a poor prognosis after PCI for patients with CKD.
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