Galovic M, et al. - Through a multicenter study with 107 adults who had temporal lobe epilepsy (TLE), researchers assessed if removing the piriform cortex is linked to postoperative seizure freedom. In the postoperative seizure-free group, a reduction in postsurgical gray matter volumes was seen in the ipsilateral piriform cortex in comparison with the non-seizure-free group. A favorable outcome was significantly inked with resecting a greater proportion of the piriform cortex (78% in seizure-free vs 46% in non–seizure-free cases in pooled data). Removal of at least half the piriform cortex significantly increased the odds of becoming seizure free by a factor of 16. Including the piriform cortex in standard anterior temporal lobe resections was supported for attaining freedom from seizure.