Petersen NH, et al. - Experts carried out a single-center prospective cohort study of individuals with large-vessel occlusion ischemic stroke who underwent endovascular therapy (ET, n = 65) in order evaluate the feasibility of ascertaining personalized BP targets as well as the relationship of diverging from these targets with radiographic and clinical outcomes. Continuous, noninvasive estimation of personalized BP targets was found out to be feasible and even following adjusting for prognostic covariates, exceeding individualized thresholds of autoregulation was related to hemorrhagic transformation and worse functional outcomes. Most individuals recruited in thrombectomy trials also received intravenous tissue plasminogen activator and were treated according to prevailing guidelines of a BP of less than 180/105 mm Hg for 24 hours. Nevertheless, recanalization rates with ET were much greater, and it continues to be unclear whether the same BP target applies. Once recanalization is accomplished, BP management above the upper limits of autoregulation may result in reperfusion injury with the consistent development of cerebral edema and hemorrhage. This phenomenon is well illustrated following carotid revascularization, however, it may also happen in acute stroke. Therefore, several thrombectomy trials intended to lower BP targets if victorious reperfusion was accomplished. Notwithstanding, the optimal BP range following ET is possible to be related to various factors, and stratifying by reperfusion status alone may not be adequate.