Juraschek SP, et al. - Researchers investigated the impact of orthostatic hypotension (OH) measurement timing on its relations to dizziness, falls, fractures, cardiovascular disease (CVD), and mortality in the ACCORD BP trial, which assessed two blood pressure (BP) goals (systolic BP [SBP]< 120 mmHg vs SBP< 140 mmHg) and incident CVD among adults with diabetes and hypertension. At baseline and follow-up visits (12 months, 48 months, and exit), seated BP was measured after 5 minutes of rest. Starting at 1 minute, with each measurement separated by 1 minute, standing BP was measured 3 consecutive times (M1-M3) after standing. A drop in SBP ≥ 20 mmHg or diastolic BP (DBP) ≥ 10 mmHg defined consensus OH. Over 8,450 visits, OH assessments were made in 4,268 participants (mean age: 62.6 years; 46.6% female; 22.3% black). There was a significant association of all measures of consensus OH with dizziness, but none showed relation to falls. A significant association of only M2 (~3 minutes) with fractures was observed. Regarding outcomes in this population of adults with hypertension and diabetes, clear superiority was not demonstrated by any single time or set of measurements. Clinically, OH evaluation by a flexibly timed, single measurement was supported.