Quinn PD, Fine KL, Rickert ME, et al. - Researchers conducted this cohort study for analyzing the correlation of opioid initiation among adolescents and young adults with subsequent broadly defined substance-related morbidity. They analyzed population-register data from January 1, 2007, to December 31, 2013, on Swedish people aged 13 to 29 years by January 1, 2013, who were naive to opioid prescription. Among the included cohort (n = 1,541,862; 793,933 male [51.5%]), 193,922 people started opioid therapy by December 31, 2013 (median age at initiation, 20.9 years [interquartile range, 18.2-23.6 years]). Data reported that the adjusted cumulative incidence of substance-related morbidity within 5 years was 6.2% for opioid recipients and 4.9% for nonsteroidal anti-inflammatory drug recipients. An initial opioid prescription receipt was correlated with a nearly 30% to 40% relative increase in the risk of subsequent substance-related morbidity in multiple confounding-adjusted designs among adolescents and young adults analyzed in this review. Such results indicate that, in some other studies, this rise could be lower than previously expected.