Huppke B, et al. - Using the medical records and database at the Center for Multiple Sclerosis (MS) in Childhood and Adolescence, Göttingen, Germany, researchers conducted this single-center retrospective study to examine the if there is a connection between obesity and pediatric risk of MS and the response to first-line therapy in children with MS. Study participants included 453 patients with pediatric MS. According to results, increased risk of pediatric MS seemed to be linked to obesity. Obese patients did not respond well to first-line drugs, and changes in pharmacokinetics appeared to be the most likely factor in response to treatment, indicating that achieving a healthy weight or adjusting the dose to body mass index might improve response to therapy. The data presented in this work showed a healthy weight could potentially optimize treatment outcomes and decrease the burden and costs of the disease.