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Association of NO 2 and other air pollution exposures with the risk of Parkinson disease

JAMA May 28, 2021

Jo S, Kim YJ, Park KW, et al. - Researchers utilized data from the Korean National Health Insurance Service in this retrospective cohort study to determine the potential link between exposure to particulate matters (PM 2.5 and PM 10 ), nitrogen dioxide (NO 2 ), ozone (O 3 ), sulfur dioxide (SO 2 ), and carbon monoxide (CO) and the risk of incident Parkinson disease (PD). This cohort analysis involved a nationally representative cohort from a metropolitan city in South Korea (n = 78,830). An elevation in PD risk was observed in relation to exposure to NO 2 . There were no statistically significant links between exposure to PM 2.5 , PM 10 , O 3 , SO 2 , or CO and PD incidence. Findings of this large cohort study revealed that NO 2 exposure was statistically significantly associated with the risk of PD. This revelation indicates that air pollutants have a role in PD development, advocating for the necessity to execute a targeted public health policy.

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