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Association of mild echocardiographic pulmonary hypertension with mortality and right ventricular function

JAMA Sep 26, 2019

Huston JH, Maron BA, French J, et al. - Researchers undertook this cohort study utilizing electronic health record data, to investigate whether there exists a link between mild echocardiographic pulmonary hypertension and reduced right ventricular function and increased risk of mortality. From March 1997 to February 2014, patients who were referred for echocardiography at Vanderbilt University Medical Center, Nashville, Tennessee, were included (n = 47,784) in this analysis. They found higher mortality, reduced right ventricular function, and impaired right ventricular–pulmonary arterial coupling among participants with mild echocardiographic pulmonary hypertension (right ventricular systolic pressure of 33 to 39 mm Hg) vs those with right ventricular systolic pressure less than 33 mm Hg. Overall, adverse right ventricular compensation and increased adjusted mortality were observed in correlation with mildly elevated pulmonary pressures in a clinical referral population.
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