Joo YS, Lee C, Kim HW, et al. - Among 4,643 people without CKD and hypertension participating in the Korean Genome and Epidemiology Study, a prospective community-based cohort study, researchers investigated if alterations in systolic BP over time could impact incident CKD development. They defined three distinct systolic BP trajectories (decreasing, stable, and increasing) applying group-based trajectory modeling. In individuals with decreasing, stable, and increasing systolic BP trajectories, CKD incidence rates were estimated to be 8.9, 9.6, and 17.8 cases per 1000 person-years, respectively. Overall, in healthy adults, a significantly raised risk of incident CKD was observed in relation to increasing systolic BP over time without reaching the hypertension threshold.