Wang JM, et al. - Via a meta-analysis, the researchers addressed the association between interferon regulatory factor (IRF)5 gene rs2004640 T/G polymorphism and systemic lupus erythematosus (SLE) susceptibility. A total of 28 comparisons, including 11,228 SLE cases and 14,374 controls were recognized. A significant correlation between allele T and SLE in overall populations was exhibited by the meta-analysis. In Asians, Europeans, and Latin Americans, stratification by ethnicity reflected strong relationships between T allele and SLE. In all people and Asians, important associations between the additive model and SLE and the dominant model and SLE was discovered. Amid the recessive mode and SLE, a marginal association was identified in overall individuals. Hence, the individuals who carried rs2004640 T allele were related to a high risk of SLE, and the IRF5 rs2004640 polymorphism had a correlation with SLE susceptibility.