Shen YC, et al. - Performing this longitudinal follow-up study, researchers examined how hysterectomies are linked with bipolar disorder risk. Using Taiwan's National Health Insurance Research Database, they selected 4,337 women 30 to 50 years of age who underwent hysterectomy and 17,348 patients without hysterectomy (1:4 match). During the follow-up of 7.93 years, bipolar disorder developed in 20 participants with hysterectomy and 28 without hysterectomy. Observations suggest an increased risk of bipolar disorder among women with hysterectomy, and a further increase in this risk was seen in relation to endometriosis and hormone therapy. Findings highlight the need to know about how mood can be influenced by surgical or natural hormonal withdrawal and emphasize the value of coordinated psychiatric and gynecological care.