Fink HA, et al. - Experts intended to inspect the tie-up between distal radius, proximal (diaphyseal) tibia and distal tibia HR-pQCT parameters measured at the Year 14 (Y14) study visit with prior clinical fracture using data from the Osteoporotic Fractures in Men (MrOS) study, a prospective cohort study of community-dwelling men aged ≥65 years. It was deduced that decreased High-resolution peripheral quantitative computed tomography (HR-pQCT) finite element analysis estimated failure loads (EFL) for each site correlated with considerably greater odds of prior confirmed clinical fracture and major osteoporotic fracture after multivariable adjustment, including for total hip areal bone mineral density (BMD). Findings illustrated that Among HR-pQCT parameters, the decreased cortical area exhibited the strongest independent association with prior clinical fracture.