Muzzio ML, Kabakian ML, Morosán-Allo Y, et al. - Researchers conducted this cross-sectional study to explore chemokine correlations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/obesity (OB). Seventy-five prepubertal children (aged: 9.0 ± 1.7years) with OW/OB were examined.  Clinical and metabolic features (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) have been evaluated. Compared with those without glomerular hyperfiltration (GH), defined as GFR >135 ml/min.1.73m², prepubertal children with GH displayed lower z-BMI, NEFA and uric acid. There were no variations in serum chemokines between children with GH or not similarly to high sensitivity C-reactive protein (hsCRP). In prepubertal children with OW/OB, GH was not related to higher chemokine levels. Decreased GFR values were associated with obesity and worse metabolic profiles, rather than elevated values. In children with severe OB, chemokines levels suggest a regulation of the immune response. There is a need for follow-up studies to address the clinical implications of these findings.