Newton ER, Akerman AW, Strassle PD, et al. - Researchers examined if and how fluoroquinolone use is associated with the rate of aortic aneurysms in US adults. They conducted a cohort study of 47,596,545 prescription fills for fluoroquinolones or a comparator antibiotic from 2005 to 2017 among commercially insured US adults aged 18 to 64 years. Findings revealed an increased rate of aortic aneurysms within 90 days after fluoroquinolone use compared with alternative antibiotic use. When stratified by age, adults 35 years or older exhibited increased incidence of aneurysms. When stratified by gender and common comorbidities (eg, hypertension and hyperlipidemia), there appeared no differences; instead, a consistent link was identified between fluoroquinolone use and aneurysm rate, indicating that both healthy and unhealthy individuals carry a risk of drug class. Based on these results, they emphasize practicing caution in using fluoroquinolones among individuals aged 35 years or older, regardless of gender or comorbidities.