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Association of estimated dietary acid load with albuminuria in Japanese adults: A cross-sectional study

BMC Nephrology Jun 07, 2019

Kabasawa K, et al. - Via cross-sectional evaluation, researchers examined the link between nutrient-derived dietary acid load and risk of albuminuria or even high normoalbuminuria in a Japanese cohort including 3250 men and 3434 women (aged 40–97 years). The participants had urine albumin-to-creatinine ratio  < 33.9 mg/mmol or estimated glomerular filtration rate ≥ 15 ml/min/1.73 m2. Among men and women, 43.4 mEq/day and 35.0 mEq/day were the median net endogenous acid production (NEAP), respectively. In multivariate analysis, 1.47 and 1.54 were identified as the adjusted odds ratio of the highest vs lowest NEAP quartile for microalbuminuria in men and women, respectively. Findings revealed an association of higher NEAP with albuminuria as well as a possible negative relation of its association to potassium intake in an adult Japanese population.
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