Heckman MG, et al. - Using a large series of neuropathologically confirmed progressive supranuclear palsy (PSP) cases, researchers comprehensively assessed the relationship between microtubule-associated protein tau (MAPT) haplotypes and the risk of PSP and the severity of tau pathology. Between January 1, 1998 and December 31, 2013 all 802 neuropathologically confirmed PSP cases were obtained from a neurodegenerative disorders brain bank and 1,312 clinical controls were obtained from the Neurology Department of the Mayo Clinic. According to this case-control study, the risk of PSP was linked to 3 MAPT H1 subhaplotypes. Furthermore, potential weaker links have been observed between several haplotypes, including some PSP risk haplotypes, and severity of tau pathology. Also noted for the haplotypes H1e and H1q were nominally significant links with severity of tau pathology. These findings broaden the current understanding of the role of MAPT haplotypic variation in PSP susceptibility and neuropathological severity.